izindaba

I-Cetylpyridinium chloride njengezindlela zokwelapha ze-COVID-19

Ukuhlolwa kukhombise imvamisa ephezulu yama-quaternary ammonium disinfectants njengezindlela zokwelapha amagciwane amaningi, kufaka phakathi ama-coronaviruses: lezi zenzo ngokwenza kungasebenzi ukuvikela i-lipid enamathela amagciwane afana ne-SARS-CoV-2 ancike kuyo. Amakhemikhali e-quaternary ammonium anconyelwa kabanzi ukubulala amagciwane futhi kunemikhiqizo engaphezu kuka-350 Ohlwini N lwe-EPA: Izibulala-magciwane ezisetshenziselwa ukuqhathanisa ne-SARS-CoV-2 (Supplementary Material. amakhemikhali asohlwini lwe-EPA abikiwe futhi> i-140 ingaliyekisa igciwane emizuzwini embalwa (18).
Lolu lwazi lusiholele ekufuneni okukhulu kwamakhemikhali e-quaternary ammonium ngomsebenzi olwa nama-coronaviruses kanye nokuhlonza okungenzeka kwamakhemikhali asevele ahlolwe emtholampilo futhi angasetshenziswa njengokwelashwa okungenzeka kube yi-COVID-19. Esinye sezibulala-magciwane esikhonjiswe njengesiqeda amagciwane (i-Supplementary Material) futhi esisetshenziswa kakhulu emikhiqizweni yokuzinakekela yi-cetylpyridinium chloride. Le nhlanganisela itholakala kakhulu ekuhlanzweni komlomo futhi ibhalwe yi-FDA njengeGenerally Conseded as Safe (GRAS) yokuthi isetshenziswe njenge-antimicrobial agent yenyama kanye nemikhiqizo yenkukhu (kufika ku-1%). I-Cetylpyridinium chloride isetshenzisiwe ezivivinyweni eziningi zemitholampilo, kufaka phakathi njengokwelashwa ngokumelene nezifo zokuphefumula okuqinisekisa ukusetshenziswa kwayo njenge-antiviral. I-Cetylpyridinium kungenzeka ikhuthaza ukungasebenzi kwegciwane ngokubhubhisa i-capsid nangokwenza kwayo i-lysosomotropic, okuxoxwe ngenhla, okujwayelekile kumakhemikhali e-quaternary ammonium. Lokhu kuphakamisa umbuzo wokuthi ngabe eminye yemithi ekhonjwe ngemishanguzo elwa namagciwane i-SARS-CoV-2 in vitro iziphatha ngendlela efanayo yini, okungukuthi ingabhubhisa i-virus capsid kanye nokuqongelela ku-lysosome noma i-endosomes futhi ekugcineni ivimbe ukungena kwegciwane. Izifundo ezengeziwe ezishicilelwe ziphakamise ukuthi lo mphumela ungancishiswa ngokusetshenziswa kwe-Cathepsin-L inhibitors. 

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I-Cetylpyridinium chloride (CPC)

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Ama-quaternary ammonium compounds anomsebenzi owaziwayo we-coronavirus

I-Molecule

Umsebenzi we-antiviral

Umshini

Kuvunyelwe i-FDA

Isebenzisa

I-ammonium chloride I-Murine coronavirus, i-hepatitis C, I-Lysosomotropic Yebo Ukusetshenziswa okuhlukahlukene kufaka phakathi i-metabolic acidosis.
I-Cetylpyridinium chloride Umkhuhlane, i-hepatitis B, i-poliovirus 1 Okuqondiwe i-capsid futhi i-lysosomotropic Yebo, GRAS I-Antiseptic, i-mouthwash, i-lozenges yokukhwehlela, imikhiqizo yokuzinakekela, izinto zokuhlanza njll

Isikhathi Iposi: Apr-16-2021